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ORIGINAL ARTICLE
Year : 2021  |  Volume : 10  |  Issue : 1  |  Page : 25-30

A surveillance study of multidrug-resistant organisms among clinically significant Gram-negative bacteria in a tertiary care teaching hospital from South India


Department of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Correspondence Address:
Jayaprada Rangineni
Assistant Professor, Department of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCSR.JCSR_116_19

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Background: Sparse published data are available from Andhra Pradesh the burden of multidrug-resistant (MDR) Gram-negative bacteria in clinical specimens. Methods: We studied the burden of MDR Gram-negative bacteria from among various clinical specimens in our tertiary care teaching institute. Results: A total of 6900 isolates were obtained of which 2960 organisms were MDR. Escherichia coli were the most frequently isolated Gram-negative species (37%), followed by Klebsiella spp. (13.4%). Pseudomonas aeruginosa, Acinetobacter spp. and Enterobacter spp. were the other commonly isolated Gram-negative organisms. High resistance rates were observed for all antimicrobials studied except for cefoperazone-sulbactam (62.6%), meropenem (70%), aminoglycosides (64%) and polymyxin B (98.6%). In spite of high resistant rates (>50%) for ciprofloxacin (80%), cephalosporins (74.4%) and cotrimoxazole (65.7%), the above-mentioned antimicrobials were clinically effective. Extended-spectrum β-lactamase production was one of the significant mechanisms of resistance in our study as β-lactam resistance was 74.4%. Conclusions: Our study documents a high proportion of resistant Gram-negative organism isolates. Clinicians should consider this while initiating antibiotic treatment.


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