| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 9
| Issue : 1 | Page : 11-15 |
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A study of prognostic significance of serum troponin I in patients with acute ischaemic stroke
Pranuthi Pynam, B Vengamma, SV Naveen Prasad, Sai Neelima Challa, R Rakesh
Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
Correspondence Address:
B Vengamma
Director Cum Vice-Chancellor, Senior Professor and Head, Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Alipiri Road, Tirupati 517 507, Andhra Pradesh
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JCSR.JCSR_87_19
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Background: Serum troponins have also been reported to be elevated in patients with acute cerebrovascular disease and poor clinical outcome.
Methods: We prospectively evaluated 360 patients with acute ischaemic stroke (AIS) to study the relationship between serum troponin I (TnI) levels and severity of AIS and to compare serum TnI levels in patients with favourable and unfavourable functional outcomes.
Results: Their mean age was 58.8 ± 13.3 years; there were 230 (63.9%) males. Majority (n = 288; 80%) had presented with anterior circulation stroke and 58 (16.1%) had posterior circulation stroke. Majority (52.5%) had large artery atherosclerosis. The median (interquartile range) National Institutes of Health Stroke Scale (NIHSS) score was 18 (16–20). Serum TnI was positive in 87 (24.2%) and negative in 273 (75.8%). The NIHSS score at admission was higher in the positive serum TnI group. Moderate-to-severe stroke, severe stroke and cardioembolic stroke were more frequently seen in the serum TnI-positive group. Outcome was favourable in 157 (47.7%) and unfavourable outcome was seen in 172 (52.3%) patients.
Conclusions: Elevated serum TnI levels were associated with increased severity of AIS and poor functional outcome.
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