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Year : 2014  |  Volume : 3  |  Issue : 4  |  Page : 224-227

Adult onset Still's disease: 7 years experience at a tertiary care centre from South India

Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, India

Correspondence Address:
A Krishna Prasad
Additional Professor, Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad
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Source of Support: None, Conflict of Interest: None

DOI: 10.15380/2277-5706.JCSR.13.067

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Background: Adult onset Still's disease (AOSD) is uncommon condition regarding which sparse published data are available from India. Methods: Retrospective study of 6 patients, who presented with pyrexia of unknown origin (PUO) seen over a 7-year period who were diagnosed to have AOSD after a thorough work-up. Results: Their mean age was 24.6 (range 18-38) years; there were four males. Mean duration of symptoms was 7.8 (range 3-5) weeks. In addition to prolonged fever, patients presented with rash, arthropathy, hepato-splenomegaly and peripheral lymphadenopathy. Laboratory evaluation revealed neutrophilic leukocytosis, hepatopathy, serositis, raised serum ferritin levels; anti-nuclear antibody and rheumatoid factor were negative in all. One patient developed acute respiratory distress syndrome and died. The remaining five patients were treated with non-steroidal anti-inflammatory drugs, oral corticosteroids, and hydroxy chloroquine and responded well to treatment. Conclusions: Increased awareness and a high index of suspicion is required for the diagnosis of AOSD. Though mortality is rare, it may occur due to complications.

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