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Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 71-75

Clinical profile of transfusion-related human immunodeficiency virus (HIV)infection in a tertiary care hospital in South India

1 Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, India
2 Department of Microbiology, Nizam's Institute of Medical Sciences, Hyderabad, India

Correspondence Address:
M.V.S Subbalaxmi
Associate Professor (Infectious Diseases), Department of GeneralMedicine, Nizam's Institute of Medical Sciences, Hyderabad 500082
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Source of Support: None, Conflict of Interest: None

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Background: Transfusion-related infection is an important mode of human immunodeficiency virus (HIV) transmission. There are very few reports in the literature on transfusion-related HIV from India. Methods: Retrospective study of clinical profile of patients with transfusion related HIV infection presenting to atertiary care hospital in South India between May 1999 to December 2011. Results: Among the 1332 records of HIV positive patients reviewed, 80 (6%) had transfusion-related HIV infection;their mean age was 32.2 ± 12.2 years; there were 47 (58.8%) women. Sixty nine patients (86.3%) were infected with HIV-1, while 11 patients (13.8%) were infected with HIV-2 The average number of units of blood transfused was 2.8. Theindications for transfusion were perioperative (n=37, 46.3%); haematologic disorders (n=15, 18.8%); trauma (n=9,11.3%); upper gastrointestinal bleed (n=3, 3.8%); miscellaneous (n=3, 3.8%) and diagnosis not clear at the time oftransfusion (n=13, 16.3%). Twenty six of the 64 patients (40.6%) had CD4+ count less than 200 cells/mm3; 32 patients(40%) were receiving highly active antiretroviral therapy. Tuberculosis was the most common opportunistic infection. Conclusions: Transfusion-related HIV infection, especially due to HIV-2 remains a significant problem in India even tillrecently; females seem to be more often affected probably due to the more frequent need for blood transfusion in themdue to gynaecologic and obstetric reasons.

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