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   2012| October-December  | Volume 1 | Issue 4  
    Online since September 18, 2018

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Molecular docking assessment of pyridone derivatives as glucokinase activators
Y Nanda Kumar, JA Pradeep Kiran, P Santhosh Kumar, S Yeswanth, K Kalpana, V Koteswara Rao, P.V.G.K Sarma, M Bhaskar
October-December 2012, 1(4):163-173
Background: Mutations in glucokinase (GK) gene results in maturity onset diabetes of the young 2 (MODY2). It has been observed that GK activators (GKAs) can activate GK structure and promote glucose phosphorylation and bring blood glucose levels to normal condition. The present study is aimed to identify the binding mode of pyridone derivatives (PDs) as GKAs through molecular docking study. Methods: GK structure was retrieved from the Protein Data Bank (PDB), protonated and energy minimized. A database was constructed with 29 PDs and docked into the allosteric site specified with Y61, R63, S69 and Y215 residues using Molecular Operating Environment (MOE) software. Docking conformations were generated using triangle match algorithm and ranked by London dG scoring function. The binding orientations and strength of interactions were evaluated by ligand interaction module of MOE. Results: Molecular docking of 29 PDs in allosteric site of GK gave reliable docking scores, interestingly arene cationic interactions were observed with the compounds PD1, PD12, PD20 and PD21. R63 residue of allosteric site played a predominant role in binding with PDs. Conclusions: PDs can be potentially useful agents in future management strategies of type 2 diabetes mellitus.
[ABSTRACT]   Full text not available  [PDF]
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Metastatic brachial plexopathy in breast cancer
T Kannan, G Sivaram Naik, KV Sreedhar Babu, B Vijayalakshmi Devi
October-December 2012, 1(4):196-198
We report the case of a 29-year-old woman previously treated for breast cancer who presented 3 years later with pain weakness and burning sensation in the left upper limb of one month duration. Electroneuromyography showed reduced sensory nerve action potential (SNAP) amplitude and reduced conduction velocity in left median nerve sensory conduction, Magnetic resonance imaging (MRI) of brachial plexus revealed nodular thickening of trunks and cords of left brachial plexus, suggesting metastasis. Ultrasonography guided fine needle aspiration cytology confirmed the presence of metastatic ductal cell carcinomatous deposits. Brachial plexopathy due to metastases from breast cancer is a rare entity, and should be kept in mind while evaluating patients with breast cancer.
[ABSTRACT]   Full text not available  [PDF]
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Disseminated tuberculosis in a patient with systemic lupus erythematosus
J Harikrishna, G Sivaram Naik, S Aparna Reddy, D Prabhath Kumar, B Siddhartha Kumar, B Vijayalakshmi Devi, N Rukmangadha, Alladi Mohan
October-December 2012, 1(4):199-203
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder. Intercurrent infections and nephritis are important causes of mortality in SLE. Among infections, tuberculosis (TB) is of particular importance as SLE patients are more susceptible to develop active TB, prior TB can precipitate SLE in genetically susceptible individuals and similar clinical presentations of SLE flare and TB may lead to delayed diagnosis. We report a patient with SLE, who developed disseminated TB. The present case highlights the importance of a high index of suspicion and focussed evaluation in the diagnosis of intercurrent infections, particularly TB in patients with SLE.
[ABSTRACT]   Full text not available  [PDF]
  20 7 -
Acute generalized exanthematous pustulosis
KS Dhillon, K Saxena, K Garg, MS Umar
October-December 2012, 1(4):192-195
Acute generalized exanthematous pustulosis (AGEP) is a rare reaction pattern with a typical morphology and a short clinical course that in majority of cases is related to medication administration. It is an acute pustular eruption with unique clinical features, a rapid clinical course and a typical histopathology. Herein, we report the case of a patient with acute generalized exanthematous pustulosis for its classical presentation.
[ABSTRACT]   Full text not available  [PDF]
  20 6 -
Ultrasound bone mineral density of Os Calcis - its relationship with bone mineral markers and 25(OH) vitamin D in endemic fluorotic and non-fluorotic villages
CV Harinarayan, T Ramalakshmi, UV Prasad, E.G.T.V Kumar, P.V.L.N Srinivasa Rao
October-December 2012, 1(4):157-162
Objectives: To study the relationship between the nutritional status, serum bone mineral markers, 25 hydroxy vitamin D [25(OH)D] levels and ultrasound bone mineral density (USBMD) of Os Calcis in subjects living in endemic fluorotic and non-fluorotic villages. Methods: Subjects from fluorotic (n=57) and non-fluorotic (n=79) villages were studied for their dietary habits, biochemical parameters of bone mineral markers, 25(OH)D levels and correlated with stiffness index (SI) measured using Achilles ultrasound bone densitometer. Results: Dietary calcium intake in both the villages is far below the recommended daily allowances (RDA) by Indian Council of Medical Research (ICMR), India for Indian population. The 25(OH)D correlated positively with energy intake (r=0.7; p<0.001); dietary calcium (r= 0.5; p<0.001); and negatively with phytate/calcium ratio (r=0.2; p<0.001), in subjects in fluorotic villages. No similar correlation was observed among subjects from non-fluorotic villages. For comparable levels of serum calcium, subjects in non-fluorotic villages were more osteopenic than the fluorotic counterparts. USBMD did not correlate with 25(OH)D in the fluorotic and non-fluorotic subjects. Conclusions: The dietary calcium intake among subjects from fluorotic and non-fluorotic villages is less than the RDA suggested by ICMR. The 25(OH)D levels of both these villages were in the vitamin D insufficiency range. USBMD does not correlate with the 25(OH)D status of an individual and it should not be used for screening osteoporosis in areas endemic for fluorosis.
[ABSTRACT]   Full text not available  [PDF]
  18 8 -
Papanicolaou (Pap) test screening of staff members of a tertiary care teaching hospital in South India
Amitabh Jena, T Bharathi, YK Siva Kumar Reddy, B Manilal, Rashmi Patnayak, BV Phaneendra
October-December 2012, 1(4):174-177
Background: In India, cancer cervix is the most common cancer among females. Papanicolaou cytological (Pap) test helps in detecting the early epithelial abnormalities in cervical cells. Material and Methods: Pap smears of female health care staff members (n=80)who underwent voluntary Pap test as part of a screening programme,from January to June 2012 were evaluated. Pap smears were evaluated by light microscopy. The 2001 Bethesda system for reporting cervical cytology was used in evaluating the pap smears. Results: Their mean age was 41.3 ± 5.6 years. Epithelial cell abnormality was noted in the Pap smear in 5 (6.3%) cases. Conclusion: Our observations provide supportive evidence for using Pap test as a tool for screening for cervical cancer. There is a need for enhancing the awareness among lay public regarding the utility of this test so that more women will avail this test and precancerous changes in cervix can be detected before they progress to frank malignancy.
[ABSTRACT]   Full text not available  [PDF]
  18 5 -
Diagnosis of viral diseases in India: at the cross roads
D.V.R Sai Gopal
October-December 2012, 1(4):155-156
Full text not available  [PDF]
  16 4 -
HIV associated thrombocytopenia
N Chandra, P Bhavnadhar, Y Satyanarayana Raju, Uppin Shanthveer
October-December 2012, 1(4):187-191
We report the case of 47-year-old male who presented with fever, cough and expectoration since 4 months and diarrhoea, malaise and dysphagia since 3 months. He was known to have diabetes mellitus and hypothyroidism and was receiving insulin and thyroxine supplementation. He was evaluated outside and was found to be co-infected with human immunodeficiency virus (HIV 1) and pulmonary tuberculosis and was receiving antituberculous treatment. He had hyperpigmented macular and non pruritic rash over his body. Oral thrush was present. Laboratory evaluation showed thrombocytopenia (20,000/μL) with giant platelets; bone marrow aspiration and biopsy revealed normocellular marrow with increased and hypolobated megakaryocytes. The patient was treated with tenofovir, emtricitabine and efavirenz, antituberculosis drugs and oral fluconazole. Insulin and thyroxine replacement therapy were continued. He was diagnosed to have HIV associated thrombocytopenia and was started on dapsone treatment. Two months later, his platelet count had become normal. The present case highlights the importance of being aware of HIV associated thrombocytopenia so as to facilitate the prompt recognition and treatment of this condition.
[ABSTRACT]   Full text not available  [PDF]
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Image challenge of the month
H Narendra, Arpana Bhide, Shankar Reddy
October-December 2012, 1(4):204-205
Full text not available  [PDF]
  13 5 -
Translational research - New opportunities
M Gourie-Devi
October-December 2012, 1(4):206-208
Full text not available  [PDF]
  12 5 -
C-reactive protein and coronary heart disease - risk marker or risk factor?
J Fiddy Davis, Sudha Vidyasagar, G Arun Maiya
October-December 2012, 1(4):178-186
Cardiovascular diseases are gaining a dubious distinction of becoming the leading cause of death. Thus, the search for new risk markers and risk factors of cardiovascular disease continue, in an attempt to predict the risk of cardiovascular events with greater precision. Of all the risk markers available, high sensitivity C-reactive Protein (hsCRP) is considered to be the most robust tool with test characteristics desirable and conducive for clinical use. Pharmacological intervention trials were successful in reducing hsCRP in individuals with elevated levels, following which its status as a therapeutic target has taken a big leap. Numerous pharmacologic and non-pharmacologic interventions are presently being investigated for their efficacy in reducing this inflammatory marker. This review discusses the stability of hsCRP, factors affecting the concentration, independent predictive ability as compared to the traditional risk factors and its role in atherogenesis.
[ABSTRACT]   Full text not available  [PDF]
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Health status of journalists
B Vengamma
October-December 2012, 1(4):209-210
Full text not available  [PDF]
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