Journal of Clinical and Scientific Research

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 9  |  Issue : 1  |  Page : 2--6

Comparison of effects of 50 μg clonidine and 5 μg dexmedetomidine on characteristics of levobupivacaine spinal block


P Aruna, M Hanumantha Rao, Pudhota Santhi Swetha, Bommala Srihari, Chetana Karuturi, Satish Kadiyala 
 Department of Anaesthesiology and Critical Care Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Correspondence Address:
M Hanumantha Rao
Dean, Senior Professor, Department of Anaesthesiology and Critical Care Medicine, Sri Venkateswara Institute of Medical Sciences, Alipiri Road, Tirupati 517 507, Andhra Pradesh
India

Background: Various adjuvants are being used with local anaesthetics for prolongation of intra- and post-operative analgesia. Methods: We randomly allocated and studied 60 patients, aged between 18 and 60 years into two groups. Group C received 3 mL (15 mg) of 0.5% isobaric levobupivacaine with 0.5 mL (50 μg) clonidine and Group D received 3 mL (15 mg) of 0.5% isobaric levobupivacaine with 0.5 mL (5 μg) dexmedetomidine. Onset and duration of sensory and motor blockade, haemodynamic parameters, and side effects were assessed. Results: Onset of sensory block (seconds) was faster in Group D than in Group C (141.7 ± 84.5 Vs 152.4 ± 77.8; P = 0.48). The mean time (minutes) for regression of sensory block to S1 dermatome was earlier in Group C compared to Group D (372.3 ± 69.3 Vs 395.3 ± 63.8; P = 0.10). The time of onset of motor block was earlier in Group D compared to Group C (3.5 ± 2.1 min Vs 3.3 ± 1.8 P = 0.81). The time required to achieve complete motor block (minutes) was more in Group C compared to Group D (9.7 ± 4.0 Vs 9.1 ± 3.1; P = 0.52). The mean time (minutes) taken for resolution of motor block was longer in Group D compared with Group C (309.5 ± 60.0 Vs 338.2 ± 61.6; P = 0.07). Conclusions: The supplementation of 50 μg clonidine and 5 μg dexmedetomidine to 0.5% isobaric levobupivacaine produced similar characteristics of the spinal block and maintained haemodynamic stability.


How to cite this article:
Aruna P, Rao M H, Swetha PS, Srihari B, Karuturi C, Kadiyala S. Comparison of effects of 50 μg clonidine and 5 μg dexmedetomidine on characteristics of levobupivacaine spinal block.J Clin Sci Res 2020;9:2-6


How to cite this URL:
Aruna P, Rao M H, Swetha PS, Srihari B, Karuturi C, Kadiyala S. Comparison of effects of 50 μg clonidine and 5 μg dexmedetomidine on characteristics of levobupivacaine spinal block. J Clin Sci Res [serial online] 2020 [cited 2020 Aug 8 ];9:2-6
Available from: http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2020;volume=9;issue=1;spage=2;epage=6;aulast=Aruna;type=0