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ORIGINAL ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 4  |  Page : 273-280

Vitamin D supplementation therapy – comparison of efficacy of three different protocols


1 Department of Endocrinology, Diabetes and Osteoporosis, Institute of Endocrinology, Diabetes and Osteoporosis, Sakra World Hospitals, Bengaluru, India
2 Department of Endocrinology, Fortis Hospitals, Bengaluru, India
3 Department of Biostatistics, National Institute of Mental Health and Neuro Sciences, Bengaluru, India
4 Department of Clinical Biochemistry, Fortis Hospitals, Bengaluru, India

Correspondence Address:
C V Harinarayan
Institute of Endocrinology, Diabetes and Osteoporosis, Sakra World Hospitals, (A kirloskar + Toyota Tsusho + Secom Hospitals Joint Venture) Sy No 52/2 & 53/3, Deverabeesanahalli, (opp Intel, Outer Ring Road,) Varathur Hobili, Marathahalli, Bengaluru 560103, Karnataka State
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.15380/2277-5706.JCSR.15.025

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Background: To study the efficacy of vitamin D supplementation therapy with three different protocols. Methods: In protocols 1 (intensive) and 3 (standard) oral cholecalciferol was given 60,000 IU/week/8 weeks followed bimonthly for 12 weeks. In protocol 2 parenteral-bolus cholecalciferol was given as 600,000 IU loading dose, 8 weeks later followed by cholecalciferol 60,000IU bimonthly for 12 weeks. Elemental calcium (1 g/day) was administered for full duration of study in all three protocols. Serum albumin, calcium, phosphorous, alkaline phosphatase, 25-hydroxy vitamin D (25OHD) and parathyroid hormone were tested at baseline, at 2nd, and 5th months. Statistical analysis was performed using random measures analysis of variance. As patients receiving protocol 3 were significantly older compared to the other two groups, age-adjusted analysis was carried out. Results: Intention-to-treat and per-protocol analysis showed that patients receiving protocol 2 had achieved 25OHD sufficiency levels at 8 weeks suggesting that protocol 2 appeared to perform best among the three protocols. However, these differences were not sustained at 5 months suggesting the need for continuing supervision. Conclusions: Despite varied responses of different biochemical markers, all three protocols were effective in bringing up 25OHD levels. However, protocol 2 performed the best among the three protocols. Our observation also highlight the importance of need for ongoing supplementation and continuing supervision of the same.


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