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ORIGINAL ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 4  |  Page : 256-265

Urinary enzymes and microalbuminuria as biomarkers of renal dysfunction after contrast administration


1 Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
2 Department of Cardiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
3 Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
4 Department of Radiodiagnosis, Sri Venkateswara Institute of Medical Sciences, Tirupati, India

Correspondence Address:
Aparna R Bitla
Associate Professor, Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.15380/2277-5706.JCSR.14.055

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Background: Contrast-induced nephropathy (CIN) is a common complication after administration of intravenous iodinated contrast media. The present study evaluated the usefulness of urinary beta-N-acetyl D-glucosaminidase (u-NAG), alkaline phosphatase (u-ALP) and lactate dehydrogenase (u-LDH) as markers of tubular injury and urinary microalbumin (u-MA) as a marker of glomerular injury for early diagnosis of CIN in patients undergoing coronary interventions. Methods: One hundred and twenty patients scheduled for elective coronary angiography (CAG), with or without angioplasty with baseline serum creatinine less than 1.2 mg/dL were recruited. Serum creatinine, u-NAG, u-ALP, u-LDH and u-MA were analyzed at 0, 4 and 24 hours after administration of low-osmolal, non-ionic contrast medium. Results: CIN developed in 27 (22.5%) patients. A significant increase in u-ALP, u-LDH and in u-MA was seen in both CIN and non-CIN groups. However, no significant difference was observed in these markers between the two groups. A significant increase in u-NAG was observed only in the CIN group. Conclusions: Low osmolal, non-ionic contrast medium produced toxic insult to the glomeruli as well as renal tubules even in patients with normal baseline renal function and u-NAG can differentiate patients with CIN.


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